Nature Search

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry.

Christopher J. Hanley
Sara Waise
Gareth J. Thomas
ResearchOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1-18
PML::RARα+ myeloid cells display metabolic alterations that can be targeted to treat resistant/relapse acute promyelocytic leukemias

Alessandra Zaza
Giuseppe Zardo
Nelida Ines Noguera
ResearchOpen Access10 Sept 2025
Leukemia

P: 1-13
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

A ‘mouse atlas’, comprising single-cell transcriptomic data from more than 100,000 cells from 20 organs and tissues, has been created as a resource for cell biology.

Nicholas Schaum
Jim Karkanias
Tony Wyss-Coray
Research03 Oct 2018
Nature

Volume: 562, P: 367-372
Capillary cell-type specialization in the alveolus

Single-cell analysis of blood vessels in the alveolus, the site of chronic disease and virus-induced lung injury, reveals two intermingled endothelial cell types with specialized gas exchange and stem cell functions.

Astrid Gillich
Fan Zhang
Ross J. Metzger
Research14 Oct 2020
Nature

Volume: 586, P: 785-789
CD99 as a novel therapeutic target on leukemic progenitor cells in FLT3-ITD^mut AML

Serena Travaglini
Tiziana Ottone
Maria Teresa Voso
Research14 Apr 2022
Leukemia

Volume: 36, P: 1685-1688
Characterization of FLT3-ITD^mut acute myeloid leukemia: molecular profiling of leukemic precursor cells

Serena Travaglini
Daniela Francesca Angelini
Tiziana Ottone
ResearchOpen Access25 Aug 2020
Blood Cancer Journal

Volume: 10, P: 1-11
Publisher Correction: Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Amendments and CorrectionsOpen Access28 Mar 2022
Nature Biotechnology

Volume: 40, P: 974
MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs’ patients

Gianfranco Catalano
Alessandra Zaza
Nelida Ines Noguera
Research22 Jun 2023
Leukemia

Volume: 37, P: 1600-1610
Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis

Giulia Falconi
Elisa Galossi
Maria Teresa Voso
ResearchOpen Access08 Dec 2022
Scientific Reports

Volume: 12, P: 1-10
Cell types of origin of the cell-free transcriptome

Cell types affected by various diseases are inferred from cell-free RNA.

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
ResearchOpen Access07 Feb 2022
Nature Biotechnology

Volume: 40, P: 855-861

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Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

PML::RARα+ myeloid cells display metabolic alterations that can be targeted to treat resistant/relapse acute promyelocytic leukemias

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

Capillary cell-type specialization in the alveolus

CD99 as a novel therapeutic target on leukemic progenitor cells in FLT3-ITD^mut AML

Characterization of FLT3-ITD^mut acute myeloid leukemia: molecular profiling of leukemic precursor cells

Publisher Correction: Cell types of origin of the cell-free transcriptome

MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs’ patients

Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis

Cell types of origin of the cell-free transcriptome

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