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Showing 1–16 of 16 results
Advanced filters: Author: Serge Charpak Clear advanced filters

  • A remerging hypothesis suggests that CO2 generated by neuronal metabolism contributes to neurovascular coupling (NVC). Here, the authors show that NVC is unaffected by the acidification of the entire arteriolar column during cerebrovascular reactivity to CO2, demonstrating that CO2 is not a mediator of NVC.

    • Marine Tournissac
    • Emmanuelle Chaigneau
    • Serge Charpak
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Neurovascular coupling refers to changes in cerebral blood flow in response to neuronal stimulation, but to what extent this change can report neuronal activation is not known. Here the authors develop transfer functions between neural calcium signals and functional ultrasound changes in blood volume in co-registered single voxel brain volumes.

    • Ali-Kemal Aydin
    • William D. Haselden
    • Davide Boido
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics of neurovascular coupling evoked by odours in the olfactory bulb.

    • Davide Boido
    • Ravi L. Rungta
    • Serge Charpak
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.

    • Ravi L Rungta
    • Serge Charpak
    News & Views
    Nature Neuroscience
    Volume: 19, P: 1539-1541

  • Fluorescence recording of neural activity in the magnetic resonance scanner is a new strategy for examining the cellular underpinnings of blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI).

    • Serge Charpak
    • Bojana Stefanovic
    News & Views
    Nature Methods
    Volume: 9, P: 547-549

  • Combination of optogenetics and BOLD fMRI is routinely used to map neuronal activity upon photostimulation. Here the authors show that light, shone at intensities used in optogenetic studies, dilates vessels and increases blood flow independently of exogenous light-sensitive proteins in the mouse brain.

    • Ravi L Rungta
    • Bruno-Félix Osmanski
    • Serge Charpak
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Here, the authors imaged calcium response in the mouse olfactory bulb in vivo to show that the calcium transients in astrocytic processes—but not cell bodies—are tightly coupled to neuronal activity and precede functional hyperemia.

    • Yo Otsu
    • Kiri Couchman
    • Serge Charpak
    Research
    Nature Neuroscience
    Volume: 18, P: 210-218

  • Understanding mechanisms of cerebral oxygen regulation is critical for healthy brain function. Here the authors show that respiration is a key modulator of cerebral oxygenation, which will be helpful in better resolving neurally-generated functional brain imaging signals, such as BOLD fMRI.

    • Qingguang Zhang
    • Morgane Roche
    • Patrick J. Drew
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Using the recently developed phosphorescent probe PtP-C343, in combination with two-photon phosphorescence lifetime microscopy, Lecoq and his colleagues offer a method for mapping oxygen levels in both microvascular and extravascular compartments with high spatial and temporal resolution. They used this set-up to make micron-scale simultaneous measurements of partial pressure of oxygen (PO2) and blood flow in the rat olfactory bulb vasculature and neuropil.

    • Jérôme Lecoq
    • Alexandre Parpaleix
    • Serge Charpak
    Research
    Nature Medicine
    Volume: 17, P: 893-898

  • Much of the current understanding of oxygen transport at the capillary level comes from mathematical models. Building on earlier work, Alexandre Parpaleix and his colleagues use two-photon phosphorescence lifetime microscopy to show how brain activity can be noninvasively imaged from measurements of oxygen dynamics in capillaries. They demonstrate the presence of an oxygen partial pressure (PO2) initial dip at the level of capillaries and show that tissue PO2 can be inferred from erythrocyte-associated transient values.

    • Alexandre Parpaleix
    • Yannick Goulam Houssen
    • Serge Charpak
    Research
    Nature Medicine
    Volume: 19, P: 241-246

  • Holographic illumination allows the production of complex, user-defined, two-dimensional illumination patterns. Used to manipulate light-sensitive molecules in cells, this system permits their simultaneous excitation at multiple locations of arbitrary shape and size—facilitating spatial and temporal regulation of cell function.

    • Christoph Lutz
    • Thomas S Otis
    • Valentina Emiliani
    Research
    Nature Methods
    Volume: 5, P: 821-827

  • Rungta et al. utilized single whisker stimulation to map out functional hyperemia along vascular arbours from layer II/III to the surface of primary somatosensory cortex, in anesthetized and awake Thy1-GCaMP6 mice. They demonstrated the presence of a functional diversity not only between different brain regions but also at the level of different vascular arbours within supragranular layers of the cerebral cortex.

    • Ravi L. Rungta
    • Marc Zuend
    • Serge Charpak
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • In this Review, Wardlaw et al. discuss the anatomy, physiology and pathology of perivascular spaces, particularly as seen with MRI in humans, and consider translation from models to humans to highlight knowns, unknowns, controversies and clinical relevance.

    • Joanna M. Wardlaw
    • Helene Benveniste
    • Sandra E. Black
    Reviews
    Nature Reviews Neurology
    Volume: 16, P: 137-153