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Showing 1–3 of 3 results
Advanced filters: Author: Sergey Proshkin Clear advanced filters

  • An ultra-high-resolution chromatin organization map of E. coli, using Micro-C, reveals intricate chromatin structures involved in the silencing of horizontally transferred genes and those associated with active operons.

    • Alexey A. Gavrilov
    • Ilya Shamovsky
    • Evgeny Nudler
    ResearchOpen Access
    Nature
    Volume: 645, P: 1060-1070

  • Here, using cryo-EM and biochemical methods, the authors demonstrate that second messenger (p)ppGpp regulates the bacterial RNA polymerase by binding to a site that is functionally relevant during transcriptional elongation but not initiation. Moreover, they demonstrate that binding to that site bears functional implications for nucleotide excision DNA repair and genome stability.

    • Jacob W. Weaver
    • Sergey Proshkin
    • Evgeny Nudler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 600-607

  • UvrD acts in nucleotide excision repair by using its helicase/translocase activity to induce RNA polymerase backtracking, enabling repair enzymes to access DNA lesions.

    • Vitaly Epshtein
    • Venu Kamarthapu
    • Evgeny Nudler
    Research
    Nature
    Volume: 505, P: 372-377