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Advanced filters: Author: Sergio Forcelloni Clear advanced filters

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control

By probing the essentiality of diverse genes encoding mRNA translation factors in different human cell types using CRISPR interference screens, Rodschinka et al. discover that human stem cells critically depend on proteins rescuing stalled or collided ribosomes.

Geraldine Rodschinka
Sergio Forcelloni
Danny D. Nedialkova
ResearchOpen Access11 Jul 2025
Nature Structural & Molecular Biology

P: 1-15
Mutations in disordered proteins as early indicators of nucleic acid changes triggering speciation

Sergio Forcelloni
Andrea Giansanti
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-8
Selective gene expression maintains human tRNA anticodon pools during differentiation

Using modification-induced misincorporation tRNA sequencing, Gao and Behrens find that on differentiation, reduced mTORC1 signalling activates MAF1, which restricts RNA polymerase III to human tRNA housekeeping genes, to ensure that tRNA anticodon pools remain stable.

Lexi Gao
Andrew Behrens
Danny D. Nedialkova
ResearchOpen Access08 Jan 2024
Nature Cell Biology

Volume: 26, P: 100-112

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