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Showing 1–7 of 7 results
Advanced filters: Author: Seth D. Crosby Clear advanced filters

  • Circadian rhythms control many physiological functions. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis — a rhythmic process that is disturbed in people with diabetes. These authors show that pancreatic islets contain their own clock: they have self-sustained circadian oscillations of CLOCK and BMAL1 genes and proteins, which are vital for the regulation of circadian rhythms. Without this clock, a cascade of cellular failure and pathology initiates the onset of diabetes mellitus.

    • Biliana Marcheva
    • Kathryn Moynihan Ramsey
    • Joseph Bass
    Research
    Nature
    Volume: 466, P: 627-631

  • Sequencing of over 600 genes in a large collection of lung adenocarcinoma samples provides an overview of somatic mutations and signalling pathways altered in cancer genes in this tumour type.

    • Li Ding
    • Gad Getz
    • Richard K. Wilson
    Research
    Nature
    Volume: 455, P: 1069-1075

  • The impact of the DART spacecraft on the asteroid Dimorphos is reported and reconstructed, demonstrating that kinetic impactor technology is a viable technique to potentially defend Earth from asteroids.

    • R. Terik Daly
    • Carolyn M. Ernst
    • Yun Zhang
    ResearchOpen Access
    Nature
    Volume: 616, P: 443-447

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29