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Showing 1–4 of 4 results
Advanced filters: Author: Seung-Bum Ko Clear advanced filters

  • The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention. Here, the authors show that, unlike in other neuropeptides, both the N-terminal and the C-terminal regions of NPY interact with the NPY receptor 1.

    • Chaehee Park
    • Jinuk Kim
    • Hee-Jung Choi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Mammals respond to bacterial infection by inducing the expression of hepcidin, which restricts serum iron levels through its effects on macrophage iron export and thereby limits systemic bacterial growth. Kim et al. now report that the macrophage-tropic pathogen Salmonella typhimurium exploits this pathway by triggering the expression of estrogen-related receptor-γ (ERR-γ), which they show increases hepcidin expression and enhances S. typhimurium growth.

    • Don-Kyu Kim
    • Jae-Ho Jeong
    • Hueng-Sik Choi
    Research
    Nature Medicine
    Volume: 20, P: 419-424

  • The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.

    • Seung-Bum Ko
    • Emiko Mihara
    • Hee-Jung Choi
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12