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Showing 1–3 of 3 results
Advanced filters: Author: Seung-Oe Lim Clear advanced filters

  • Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.

    • Chia-Wei Li
    • Seung-Oe Lim
    • Mien-Chie Hung
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.

    • Jung-Mao Hsu
    • Weiya Xia
    • Mien-Chie Hung
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17