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Showing 1–6 of 6 results
Advanced filters: Author: Sevi Durdu Clear advanced filters

  • Co-deletion of all proteins with a functional methyl-CpG-binding domain does not impact genes or repeats silenced by DNA methylation. Analysis of chromatin accessibility and sequence motifs identifies transcription factors that appear sensitive to DNA methylation.

    • Sebastian Kaluscha
    • Silvia Domcke
    • Dirk Schübeler
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1895-1906

  • The removal of dying neurons by microglia plays a key role in both vertebrate nervous system development and several diseases. Here, the authors use a quantitative live imaging approach to investigate neuronal-microglial interactions at single-cell resolution and establish the functions of the phosphatidylserine receptors, TIM-4 and BAI1, in neuronal engulfment.

    • Fargol Mazaheri
    • Oksana Breus
    • Francesca Peri
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • BANP is identified as the transcription factor that binds the CGCG element in a DNA-methylation-dependent manner, opens chromatin and activates a class of essential CpG-island-regulated genes.

    • Ralph S. Grand
    • Lukas Burger
    • Dirk Schübeler
    Research
    Nature
    Volume: 596, P: 133-137

  • It is widely accepted that migrating cells and tissues navigate along pre-patterned chemoattractant gradients; here it is shown that migrating tissues can also determine their own direction by generating local gradients of chemokine activity, via polarized receptor-mediated internalization, that are sufficient to ensure robust collective migration.

    • Erika Donà
    • Joseph D. Barry
    • Darren Gilmour
    Research
    Nature
    Volume: 503, P: 285-289