This study answers the long-standing question of why the interaction between cyclophilin A (CypA) and HIV-1 capsid (CA) protein stimulates HIV-1 infectivity in human cells. Disruption of the CA−CypA interaction renders HIV-1 susceptible to potent restriction by human TRIM5α in primary blood cells, which occurs before reverse transcription.
- Kyusik Kim
- Ann Dauphin
- Jeremy Luban
