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Showing 1–8 of 8 results
Advanced filters: Author: Seychelle M. Vos Clear advanced filters

  • Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights into the mechanism of chromatin transcription.

    • Lucas Farnung
    • Seychelle M. Vos
    • Patrick Cramer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-6

  • The cryo-electron microscopy structure of a paused transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and negative elongation factor is reported at 3.2 Å resolution.

    • Seychelle M. Vos
    • Lucas Farnung
    • Patrick Cramer
    Research
    Nature
    Volume: 560, P: 601-606

  • In this study, the authors present the cryogenic electron microscopy reconstruction of the Rpd3S complex engaged with a nucleosome. The corresponding model describes the interactions that facilitate histone deacetylation within gene bodies by the Rpd3S complex.

    • Jonathan W. Markert
    • Seychelle M. Vos
    • Lucas Farnung
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • The cryo-electron microscopy structure of an activated transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and the elongation factors PAF1 complex and SPT6 is reported at 3.1 Å resolution.

    • Seychelle M. Vos
    • Lucas Farnung
    • Patrick Cramer
    Research
    Nature
    Volume: 560, P: 607-612

  • Transcription of eukaryotic protein-coding genes involves co-activator complexes, including TFIID and SAGA. A new study has determined the first high-resolution cryo-EM structure of the human SAGA complex, and has implications for defining SAGA function during multiple stages of eukaryotic transcription.

    • Seychelle M. Vos
    News & Views
    Nature Structural & Molecular Biology
    Volume: 28, P: 959-960

  • To maintain chromosome superstructure and integrity, topoisomerases resolve specific DNA superstructures or intermediates that arise from processes such as DNA repair, transcription and replication, and chromosome compaction. Despite decades of study, new insights into the cellular function and regulation of topoisomerases, as well as their use as therapeutic targets, continue to emerge.

    • Seychelle M. Vos
    • Elsa M. Tretter
    • James M. Berger
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 827-841