Diazo compounds are invaluable intermediates in organic synthesis, however, traditional C–H diazotization methods often face environmental and safety challenges due to the use of azide compounds and excessive acid/base. Here, the authors introduce a protocol using 2-methoxyethyl nitrite, achieving efficient diazotization of 2-substituted indoles with high reactivity and selectivity.
- Airu Hashidoko
- Taku Kitanosono
- Shū Kobayashi
