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Showing 1–7 of 7 results

Advanced filters: Author: Shadmehr Demehri Clear advanced filters

Hepatitis B virus promotes liver cancer by modulating the immune response to environmental carcinogens

Hepatitis B virus (HBV) infection is associated with hepatitis and hepatocellular carcinoma (HCC). Here, the authors show that HBV promotes HCC formation only in response to environmental carcinogens, involving increased IL-33 signaling and regulatory T cells.

Mei Huang
Dongyao Wang
Shadmehr Demehri
ResearchOpen Access27 Jun 2025
Nature Communications

Volume: 16, P: 1-13
Reply to: Beta human papillomaviruses and skin cancer

John D. Strickley
Jonathan L. Messerschmidt
Shadmehr Demehri
Research16 Dec 2020
Nature

Volume: 588, P: E22-E23
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression

Interleukin-33 (IL-33) is a master initiator of cancer-prone chronic inflammation. Here, the authors show that TLR3/4-TBK1-IRF3 pathway activation induces IL-33, and the cholesterol-lowering drug, statin, blocks this pathway to suppress chronic inflammation and its cancer sequela.

Jong Ho Park
Mahsa Mortaja
Shadmehr Demehri
ResearchOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-15
Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity

Masayoshi Kawakubo
Trevor J. Cunningham
Dieter Manstein
ResearchOpen Access06 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
Immunity to commensal papillomaviruses protects against skin cancer

A mouse model of papillomavirus infection reveals that skin colonization with commensal papillomaviruses protects the immunocompetent host against chemical- and UV-induced skin cancer through CD8⁺ T cell immunity.

John D. Strickley
Jonathan L. Messerschmidt
Shadmehr Demehri
Research30 Oct 2019
Nature

Volume: 575, P: 519-522
Combined PD-1, BRAF and MEK inhibition in BRAF^V600E colorectal cancer: a phase 2 trial

Patients with BRAF^V600E-mutated colorectal cancer have encouraging overall response rates to inhibition of PD-1, BRAF and MEK, with translational analyses suggesting that induction of tumor-intrinsic programs and immune programs contributes to improved outcomes via MAPK inhibition.

Jun Tian
Jonathan H. Chen
Ryan B. Corcoran
ResearchOpen Access26 Jan 2023
Nature Medicine

Volume: 29, P: 458-466
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

BiTE-secreting CAR-T cells overcome antigen escape from EGFRvIII-targeted therapy for glioblastoma.

Bryan D. Choi
Xiaoling Yu
Marcela V. Maus
Research22 Jul 2019
Nature Biotechnology

Volume: 37, P: 1049-1058