Amyloid fibrils can accumulate in tissues outside the brain, yet the impact is incompletely understood. Here the researchers show that, with age, mouse bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. Clearing senescent fat cells or depleting SAP/PTX2 reduces marrow amyloid deposits and restores bone health.
- Surendra Kumar
- Kangping Song
- Mei Wan
