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Showing 1–2 of 2 results
Advanced filters: Author: Shaima’a Hamarsheh Clear advanced filters

  • Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical work on the immune modulatory effects of oncogenic KRAS and the potential clinical application.

    • Shaima’a Hamarsheh
    • Olaf Groß
    • Robert Zeiser
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.

    • Shaima’a Hamarsheh
    • Lena Osswald
    • Robert Zeiser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17