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Advanced filters: Author: Shakson Isaac Clear advanced filters

Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo

During sea urchin development, the micromeres form via asymmetric cell division and act as organizers to induce gastrulation. Here they show that micromeres have unique metabolic characteristics and that disrupting their metabolic activity blocks gastrulation induction.

Shakson Isaac
Douglas Dubosky
Mamiko Yajima
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles

SCENT is a nonparametric method that models association between chromatin accessibility and gene expression in single-cell multimodal datasets, enabling construction of cell-type-specific enhancer–gene maps to aid mapping of candidate causal variants and genes for common diseases.

Saori Sakaue
Kathryn Weinand
Soumya Raychaudhuri
Research09 Apr 2024
Nature Genetics

Volume: 56, P: 615-626
The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.

Christopher Noyes
Shunsuke Kitajima
Mamiko Yajima
ResearchOpen Access18 Jan 2023
Communications Biology

Volume: 6, P: 1-14