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Showing 1–4 of 4 results
Advanced filters: Author: Shalini T Low-Nam Clear advanced filters

  • The linker for activation of T cells (LAT) protein is involved in the activation of T cells. Here the authors discover micron scale LAT condensation events downstream of singly bound T-cell receptors during T cell activation and characterise how LAT condensation timing affects downstream T cell signalling.

    • Darren B. McAffee
    • Mark K. O’Dair
    • Jay T. Groves
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • The guanine nucleotide exchange factor SOS is a critical intermediary that transduces receptor tyrosine kinase stimulation into Ras activation. Here the authors develop a single molecule assay in which SOS is captured from raw lysates using Ras-functionalized membrane microarrays and uncover an autoinhibitory mechanism of SOS regulation.

    • Young Kwang Lee
    • Shalini T. Low-Nam
    • Jay T. Groves
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Two distinct and opposing models for clathrin-mediated endocytosis have been inferred from EM and structural biology data. Here the authors develop an optical method to directly visualize membrane-bending dynamics and show that coat assembly accommodates membrane bending during or after the assembly of the clathrin lattice, which is not predicted by either model.

    • Brandon L. Scott
    • Kem A. Sochacki
    • Adam D. Hoppe
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Dimerization, ligand-binding and co-confinement are all expected to contribute to erbB1 signaling, but the level of their contribution has not yet been fully appreciated. Two-color quantum-dot tracking in live cells now shows that ligand-binding (two ligands with two receptors) stabilizes erbB1 dimers, whereas actin networks influence dimer mobility and promote repeated encounters between erbB1 monomers.

    • Shalini T Low-Nam
    • Keith A Lidke
    • Diane S Lidke
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1244-1249