The authors discuss a novel strategy of increasing the elevated intracellular levels of reactive oxygen species, which result from aberrantly-regulated signaling pathways, to a lethal level in tumor cells only. The selective death of cancer cells might be exploited in order to develop highly effective and specific therapeutic strategies with minimal side effects for the treatment of urothelial carcinoma.
- Hwa-Chain R. Wang
- Shambhunath Choudhary