Fibrotic disease can affect almost all organs, and only few therapies currently exist for the treatment of fibrosis. This Review discusses the contribution of mechanical forces to the onset and progression of fibrosis, highlighting distinct mechanotransduction mechanisms as well as engineered models and therapeutic approaches targeting mechanotransduction pathways for the investigation and treatment of fibrosis, respectively.
- Shamik Mascharak
- Jason L. Guo
- Michael T. Longaker
