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Showing 1–4 of 4 results
Advanced filters: Author: Shankha Satpathy Clear advanced filters

  • Connecting genomics and proteomics allows the development of more efficient and specific treatments for cancer. Here, the authors develop proteogenomic methods to defining cancer signaling in-vivo starting from core needle biopsies and with application to a HER2 breast cancer focused clinical trial.

    • Shankha Satpathy
    • Eric J. Jaehnig
    • Matthew J. Ellis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • This Review examines recent developments in proteogenomics, key findings from the proteogenomic analyses of a wide range of cancers and emerging applications of proteogenomics to translational studies and immuno-oncology, as well as discussing future prospects regarding integration into clinical trials and patient care.

    • D. R. Mani
    • Karsten Krug
    • Steven A. Carr
    Reviews
    Nature Reviews Cancer
    Volume: 22, P: 298-313

  • Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.

    • Namrata D. Udeshi
    • Deepak C. Mani
    • Steven A. Carr
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Patient samples are often available in limited amounts, restricting the number of possible omics analyses. Here the authors present MONTE, a workflow that enables serial HLA-I and HLA-II immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome data collection from patient samples.

    • Jennifer G. Abelin
    • Erik J. Bergstrom
    • Steven A. Carr
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22