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Gremlin 1⁺ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1⁺ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.

Varun N. Kapoor
Sören Müller
Shannon J. Turley
Research26 Apr 2021
Nature Immunology

Volume: 22, P: 571-585
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Fibroblastic reticular cells (FRCs) are dynamic regulators of lymphoid tissue structure. Turley and colleagues show FRCs also support activated T cells by producing IL-6, which confers an advantage to CD8+ T cell memory responses.

Flavian D. Brown
Debattama R. Sen
Shannon J. Turley
Research21 Oct 2019
Nature Immunology

Volume: 20, P: 1668-1680
Mechanosensing by Peyer’s patch stroma regulates lymphocyte migration and mucosal antibody responses

Peyer’s patches (PPs) are sites of antibody production in the gut mucosa. Carroll and colleagues show the mechanosensory channel protein Piezo1 is required for the homeostatic maintenance of PPs. Specific loss of Piezo1 in FRCs disrupt PP structure and function, resulting in reduction of fecal IgA production and gut immunity.

Jonathan E. Chang
Matthew B. Buechler
Michael C. Carroll
Research14 Oct 2019
Nature Immunology

Volume: 20, P: 1506-1516
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance

Timblin et al. demonstrate that LPS or hydroxyoestrogen-induced mitochondrial stress triggers mitohormesis in macrophages, restraining inflammatory gene activation by suppressing oxidative metabolism.

Greg A. Timblin
Kevin M. Tharp
Kaoru Saijo
Research20 May 2021
Nature Metabolism

Volume: 3, P: 618-635
Correction: Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Htoo A. Wai
Jenny Lord
L. Archer
Amendments and CorrectionsOpen Access01 Apr 2020
Genetics in Medicine

Volume: 22, P: 1129
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster

First responders to the World Trade Center disaster, who were exposed to particulate matter containing potential carcinogens, have a high burden of somatic mutations in blood cells, raising their risk for cancer and other diseases and highlighting the need for enhanced health screening of these individuals.

Sakshi Jasra
Orsi Giricz
Amit Verma
Research07 Mar 2022
Nature Medicine

Volume: 28, P: 468-471
Selection homophily and peer influence for adolescents’ smoking and vaping norms and outcomes in high and middle-income settings

Jennifer M. Murray
Sharon C. Sánchez-Franco
Ruth F. Hunter
ResearchOpen Access26 Sept 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-35
The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study

C Mitchell
P Morris Jones
J Pritchard
ResearchOpen Access08 Aug 2000
British Journal of Cancer

Volume: 83, P: 602-608
Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Htoo A. Wai
Jenny Lord
L. Archer
ResearchOpen Access03 Mar 2020
Genetics in Medicine

Volume: 22, P: 1005-1014
A microRNA expression and regulatory element activity atlas of the mouse immune system

Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq, ChIP–seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.

Samuel A. Rose
Aleksandra Wroblewska
Aldrin Yim
Research07 Jun 2021
Nature Immunology

Volume: 22, P: 914-927
Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

Marcal Yll-Pico
Yoonsuh Park
Don J. Diamond
ResearchOpen Access30 Mar 2024
npj Vaccines

Volume: 9, P: 1-11
Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

Chiuppesi et al. demonstrate that COVID-19 vaccine COH04S1, harboring a synthetic modified vaccinia Ankara-vector, elicits cross-reactive responses against mpox virus (MPXV) similar to those induced by FDA-approved mpox vaccine JYNNEOS in healthy adults and non-human primates. COH04S1 also confers protective immunity against MPXV in a mouse model of mpox.

Flavia Chiuppesi
John A. Zaia
Don J. Diamond
ResearchOpen Access16 Feb 2024
Communications Medicine

Volume: 4, P: 1-9
Lymph node stromal cells: cartographers of the immune system

Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.

Akshay T. Krishnamurty
Shannon J. Turley
Reviews23 Mar 2020
Nature Immunology

Volume: 21, P: 369-380
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Ira Adams-Chapman
Kristi L. Watterberg
Marian Willinger
Research23 Mar 2021
Journal of Perinatology

Volume: 41, P: 2072-2087
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green
Jon E. Tyson
Kimberlee Weaver-Lewis
ResearchOpen Access04 Aug 2023
Journal of Perinatology

Volume: 43, P: 1398-1405

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