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Showing 1–2 of 2 results
Advanced filters: Author: Shanu Jain Clear advanced filters
  • Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications.

    • Sai P. Pydi
    • Shanu Jain
    • Jürgen Wess
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14
  • During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled receptors, is essential for beta-cell replication and function in insulin-resistant mice.

    • Luiz F. Barella
    • Mario Rossi
    • Jürgen Wess
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14