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Showing 1–2 of 2 results
Advanced filters: Author: Sharad Mistry Clear advanced filters

  • Protein kinases expressed by the malaria parasite Plasmodium falciparum represent potentially valuable drug targets. Alam et al. identify proteins whose phosphorylation is dependent on the kinase PfPKG, revealing a regulatory network controlling parasite egress from red blood cells and calcium signalling.

    • Mahmood M. Alam
    • Lev Solyakov
    • Andrew B. Tobin
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • New approaches are required to combatPlasmodium falciparuminfection. In this proteome-wide study, 1305 phosphorylation sites are identified and 36 kinases are shown to have crucial roles in parasite survival, providing new insights into parasite biology and potential new drug targets for anti-malarial chemotherapy.

    • Lev Solyakov
    • Jean Halbert
    • Christian Doerig
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-12