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Nature Biomedical Engineering (1)

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Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

The overexpression of β-catenin and the transcription factor Gata4 in skin fibroblasts induces these cells to secrete reparative exosomes, as shown in mice models of myocardial infarction and Duchenne muscular dystrophy.

Ahmed G. E. Ibrahim
Chang Li
Eduardo Marbán
Research26 Aug 2019
Nature Biomedical Engineering

Volume: 3, P: 695-705

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Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

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