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Showing 1–3 of 3 results

Advanced filters: Author: Sharon Gowan Clear advanced filters

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Chemoproteomic studies have revealed that a Wnt-pathway inhibitor, CCT251545, is a potent and selective small-molecule chemical probe that inhibits the Mediator complex–associated protein kinases CDK8 and CDK19 through a type 1 binding mode and modulates the growth of Wnt-dependent tumors.

Trevor Dale
Paul A Clarke
Julian Blagg
Research26 Oct 2015
Nature Chemical Biology

Volume: 11, P: 973-980
Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma

Nada M. S. Al-Saffar
Helen Troy
Yuen-Li Chung
ResearchOpen Access31 Oct 2018
British Journal of Cancer

Volume: 119, P: 1118-1128
ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-selected pink bollworm

Lolita G. Mathew
Jeyakumar Ponnuraj
Jeffrey A. Fabrick
ResearchOpen Access10 Sept 2018
Scientific Reports

Volume: 8, P: 1-15