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Advanced filters: Author: Sharwari Verma Clear advanced filters

  • p38α MAP kinase is activated by autophosphorylation, which is promoted by the protein TAB1 during myocardial ischemia and other stresses. Now cellular, biochemical and biophysical approaches reveal that TAB1 binds p38α's C-terminal kinase lobe and induces rearrangements within the activation segment that allow autophosphorylation in cis.

    • Gian Felice De Nicola
    • Eva Denise Martin
    • Michael S Marber
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1182-1190