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Showing 1–7 of 7 results
Advanced filters: Author: Shaun P Falk Clear advanced filters

  • A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

    • Vilma Lammi
    • Tomoko Nakanishi
    • Hanna M. Ollila
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1402-1417

  • The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

    • Tarjei S. Mikkelsen
    • Matthew J. Wakefield
    • Kerstin Lindblad-Toh
    Research
    Nature
    Volume: 447, P: 167-177

  • Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

    • Colm O'Dushlaine
    • Lizzy Rossin
    • Gerome Breen
    Research
    Nature Neuroscience
    Volume: 18, P: 199-209

  • The Psychiatric GWAS Consortium Bipolar Disorder Working Group reports a large-scale genome-wide association study of 7,481 individuals with bipolar disorder with replication in 4,493 cases. The Consortium identifies a new susceptibility locus near ODZ4 and replicates a known association near CACNA1C for bipolar disorder.

    • Pamela Sklar
    • Stephan Ripke
    • Shaun M Purcell
    Research
    Nature Genetics
    Volume: 43, P: 977-983

  • Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

    • S Hong Lee
    • Stephan Ripke
    • Naomi R Wray
    Research
    Nature Genetics
    Volume: 45, P: 984-994

  • Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

    • Simone de Jong
    • Mateus Jose Abdalla Diniz
    • Gerome Breen
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-10