Nature Search

Protease-activated receptor 3 is a second thrombin receptor in humans

Hiroaki Ishihara
Andrew J. Connolly
Shaun R. Coughlin
Research03 Apr 1997
Nature

Volume: 386, P: 502-506
Role of the thrombin receptor in development and evidence for a second receptor

Andrew J. Connolly
Hiroaki Ishihara
Shaun R. Coughlin
Research06 Jun 1996
Nature

Volume: 381, P: 516-519
Domains specifying thrombin–receptor interaction

Thien-Khai H. Vu
Virginia I. Wheaton
Shaun R. Coughlin
Research17 Oct 1991
Nature

Volume: 353, P: 674-677
Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

Robert E. Gerszten
Ji Chen
Shaun R. Coughlin
Research14 Apr 1994
Nature

Volume: 368, P: 648-651
Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

Thrombin is a key proinflammatory protease regulating leukocyte trafficking at sites of vascular injury. Here the authors show that balanced thrombin interactions with platelet proteins PAR4, GPIbα and fibrin plays a major role in regulating this process.

Zane S. Kaplan
Alessandro Zarpellon
Shaun P. Jackson
Research23 Jul 2015
Nature Communications

Volume: 6, P: 1-13
Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

Shaun R. Coughlin
Michael A. Moskowitz
Lawrence Levine
Research11 Dec 1980
Nature

Volume: 288, P: 600-602
Role of thrombin signalling in platelets in haemostasis and thrombosis

Gilberto R. Sambrano
Ethan J. Weiss
Shaun R. Coughlin
Research06 Sept 2001
Nature

Volume: 413, P: 74-78
High-resolution crystal structure of human protease-activated receptor 1

The X-ray crystal structure of the human G-protein-coupled receptor protease-activated receptor 1 (PAR1) bound to the antagonist vorapaxar is solved, revealing an unusual method of drug binding that should facilitate the development of improved PAR1-selective antagonists.

Cheng Zhang
Yoga Srinivasan
Brian K. Kobilka
Research09 Dec 2012
Nature

Volume: 492, P: 387-392
PAR3 is a cofactor for PAR4 activation by thrombin

Mayumi Nakanishi-Matsui
Yao-Wu Zheng
Shaun R. Coughlin
Research06 Apr 2000
Nature

Volume: 404, P: 609-613
A dual thrombin receptor system for platelet activation

Mark L. Kahn
Yao-Wu Zheng
Shaun R. Coughlin
Research13 Aug 1998
Nature

Volume: 394, P: 690-694
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

The activity of serine proteases, including CAP1/Prss8, is altered in some human skin disorders; however, the downstream effectors of these proteins are relatively unknown. Here, using animal models, the authors show that protease-activated receptor-2 is a critical component of the CAP1/Prss8 signalling cascade.

Simona Frateschi
Eric Camerer
Edith Hummler
ResearchOpen Access18 Jan 2011
Nature Communications

Volume: 2, P: 1-11
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac function and recapitulate disease-related phenotypes.

Nathan Orr
Rima Arnaout
Michael H. Gollob
ResearchOpen Access12 Apr 2016
Nature Communications

Volume: 7, P: 1-8
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

Functional analysis of membrane proteins would benefit from the combination of imaging with ligand characterisation. Here, Pfreundschuh et al. use specialised atomic force microscopy tips to image and quantify the binding of two ligands at the same time.

Moritz Pfreundschuh
David Alsteens
Daniel J. Müller
ResearchOpen Access12 Nov 2015
Nature Communications

Volume: 6, P: 1-7
hCDC5: A HUMAN HOMOLOG OF Schizosaccharomyces pombe cdc5.• 119

Harold S Bernstein
Shaun R Coughlin
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 22
Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography

Functional imaging of proteolytic activity is an emerging strategy to guide patient diagnosis and monitor clinical outcome. Here the authors present a peptide-based probe to detect and localize thrombin activity ex vivoand non-invasively in mouse models of wounding and pulmonary thrombosis.

Michael J. Page
André L. Lourenço
Charles S. Craik
ResearchOpen Access01 Oct 2015
Nature Communications

Volume: 6, P: 1-11
Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape

A force-distance curve–based atomic force microscopy method is developed and applied to both image and quantify the ligand-binding free-energy landscape of single protease-activated receptor-1 (PAR1) molecules under physiologically relevant conditions.

David Alsteens
Moritz Pfreundschuh
Daniel J Müller
Research13 Jul 2015
Nature Methods

Volume: 12, P: 845-851
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

The environmental cues involved in regulating germinal center size are not fully understood. Cyster and colleagues show that the sphingosine 1-phosphate receptor S1P₂ controls the survival and localization of B cells in germinal centers by antagonizing signaling by the kinase Akt and follicular chemoattractants.

Jesse A Green
Kazuhiro Suzuki
Jason G Cyster
Research05 Jun 2011
Nature Immunology

Volume: 12, P: 672-680
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax

Caroline A. Coughlin
Dhanvantri Chahar
Jonathan H. Schatz
ResearchOpen Access02 Feb 2025
Blood Cancer Journal

Volume: 15, P: 1-14
Microglial G_i-dependent dynamics regulate brain network hyperexcitability

Merlini, Rafalski et al. show that dynamic microglial brain surveillance prevents hyperexcitability and seizures by G_i-dependent microglia–neuron interactions in response to evoked neuronal activity to maintain physiological network synchronization.

Mario Merlini
Victoria A. Rafalski
Katerina Akassoglou
Research14 Dec 2020
Nature Neuroscience

Volume: 24, P: 19-23
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

A transmembrane O-glycoprotein podoplanin (PDPN) expressed on fibroblastic reticular cells is the activating ligand for platelet receptor CLEC-2; this interaction leads to perivenular release of sphingosine-1-phosphate and expression of VE-cadherin on high endothelial venules, a key process for the maintenance of vascular integrity in lymph nodes.

Brett H. Herzog
Jianxin Fu
Lijun Xia
Research01 Sept 2013
Nature

Volume: 502, P: 105-109
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Direct imaging of the lung microcirculation in mice indicates that it is a major site of mature platelet production from megakaryocytes.

Emma Lefrançais
Guadalupe Ortiz-Muñoz
Mark R. Looney
Research22 Mar 2017
Nature

Volume: 544, P: 105-109
Thrombin signalling and protease-activated receptors

Shaun R. Coughlin
Reviews14 Sept 2000
Nature

Volume: 407, P: 258-264
Overview of the Alliance for Cellular Signaling

Alfred G. Gilman
Melvin I. Simon
Gilberto R. Sambrano
Editorial12 Dec 2002
Nature

Volume: 420, P: 703-706

Search

Protease-activated receptor 3 is a second thrombin receptor in humans

Role of the thrombin receptor in development and evidence for a second receptor

Domains specifying thrombin–receptor interaction

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

Role of thrombin signalling in platelets in haemostasis and thrombosis

High-resolution crystal structure of human protease-activated receptor 1

PAR3 is a cofactor for PAR4 activation by thrombin

A dual thrombin receptor system for platelet activation

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

hCDC5: A HUMAN HOMOLOG OF Schizosaccharomyces pombe cdc5.• 119

Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography

Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape

The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax

Microglial G_i-dependent dynamics regulate brain network hyperexcitability

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Thrombin signalling and protease-activated receptors

Overview of the Alliance for Cellular Signaling

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