A new study identifies a list of genes synergistically regulated by the Ras oncogene and loss of the p53 tumour suppressor gene. A high proportion of these genes are essential for tumour formation in vivo, whereas only very few of the genes regulated by only either Ras or p53 are important. This establishes a new approach to finding genes important in tumourigenesis that may also represent novel targets for tumour therapy.
- Helene R. McMurray
- Erik R. Sampson
- Hartmut Land
