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Showing 1–3 of 3 results
Advanced filters: Author: Shelby A. Roseman Clear advanced filters

  • Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and an essential function of H3K27me3 in regulating sub-compartments and lamina association.

    • Allison P. Siegenfeld
    • Shelby A. Roseman
    • Brian B. Liau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The authors reveal that the chromatin architectural proteins CTCF and RAD21 organize DNA around nuclear speckles to enhance gene induction. This structural organization, when disrupted as in Cornelia de Lange syndrome, impairs key gene functions, providing insight into potential disease mechanisms.

    • Ruofan Yu
    • Shelby Roseman
    • Shelley L. Berger
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1069-1080