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Advanced filters: Author: Shelly A Buffington Clear advanced filters

  • The authors show that phosphorylation of the translation factor eIF2α is necessary and sufficient for mGluR-LTD. They identify mRNAs that are translated during mGluR-LTD and regulated by p-eIF2α, including Ophn1 as a key target. Deficient p-eIF2α-mediated translation impairs object-place learning, which requires mGluR-LTD. eIF2α phosphorylation may determine whether synapses undergo LTD or LTP.

    • Gonzalo Viana Di Prisco
    • Wei Huang
    • Mauro Costa-Mattioli
    Research
    Nature Neuroscience
    Volume: 17, P: 1073-1082