PCTR1, via the activation of the lipoxin A4 receptor, promotes the conversion of linoleic acid to arachidonic acid (AA) through upregulation of the desaturases FADS1, FADS2, and ELOVL2 expression. It also inhibits the conversion of bound AA into free AA through downregulation of phospholipase A2 expression, resulting in decreases in serum AA and prostaglandin E2 levels, resulting in an anti-inflammatory effect and organ protection.
- Yong-jian Liu
- Hui Li
- Sheng-wei Jin