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Showing 1–5 of 5 results
Advanced filters: Author: Shernaz X. Bamji Clear advanced filters

  • Drugs of abuse alter the strength of synaptic connections within the mesocorticolimbic dopamine system. The current study demonstrates that this is dependent on the recruitment of cadherin to the synaptic membrane. Increased cadherin at dopaminergic synapses impairs cocaine-induced synaptic plasticity, resulting in a reduction in cocaine preference.

    • Fergil Mills
    • Andrea K Globa
    • Shernaz X Bamji
    Research
    Nature Neuroscience
    Volume: 20, P: 540-549

  • Synaptic plasticity is mediated by the dynamic localization of proteins at synapses, which is partly controlled via palmitoylation of synaptic proteins. Here, the authors show how neuronal activity regulates the palmitoylation reaction through the translocation of the palmitoyl-acyl transferase DHHC5.

    • G. Stefano Brigidi
    • Brendan Santyr
    • Shernaz X. Bamji
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-17

  • This study shows that activity-dependent palmitoylation of δ-catenin stabilizes the cell adhesion molecule N-cadherin at the excitatory synapse and that this post-translational modification is important for GluA1- and GluA2-mediated synaptic and structural plasticity.

    • G Stefano Brigidi
    • Yu Sun
    • Shernaz X Bamji
    Research
    Nature Neuroscience
    Volume: 17, P: 522-532

  • Mutations in PTEN have been associated with various human disease, including autism spectrum disorder (ASD) and cancer. Here, the authors assess the function of 106 PTEN variants in yeast, invertebrate models and cell culture and report that PTEN variants generally decrease protein stability.

    • Kathryn L. Post
    • Manuel Belmadani
    • Kurt Haas
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Protein S-acylation is involved in many pathophysiological processes. Here, Mesquita et al. discuss the structure, function and regulation of S-acylation and deacylation enzymes and describe how this post-transcriptional modification precisely controls protein–cell membrane interactions. Potential therapeutic applications of S-acylation are also highlighted.

    • Francisco S. Mesquita
    • Laurence Abrami
    • F. Gisou van der Goot
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 488-509