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Ferroelectric Polarization Reversal Stabilized by Hydrogen Bonding in N-Phenylated Aromatic Polyurea

Shigeru Tasaka
Kazuya Ohishi
Seizo Miyata
Research01 Apr 1994
Polymer Journal

Volume: 26, P: 505-507
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

Kazuyoshi Takeda
Yoshihiro Hayakawa
Ko Okumura
Research01 Jan 2001
Nature Medicine

Volume: 7, P: 94-100
Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T_reg cells through modification of the intestinal microbiota

The cytokines IL-17A and IL-17F bind via same receptor. Iwakura and colleagues demonstrate different functions for IL-17A and IL-17F in the gut, with the latter altering the production of antimicrobial peptides with consequent effects on the microbiota, the induction of T_reg cells and immune-system homeostasis.

Ce Tang
Shigeru Kakuta
Yoichiro Iwakura
Research18 Jun 2018
Nature Immunology

Volume: 19, P: 755-765
CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

The complement system contributes to chronic inflammatory diseases. Here the authors show that CRTP6 suppresses the alternative complement pathway and reverses rheumatoid arthritis in a mouse model of the disease.

Masanori A. Murayama
Shigeru Kakuta
Yoichiro Iwakura
ResearchOpen Access25 Sept 2015
Nature Communications

Volume: 6, P: 1-12
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2⁺Vγ6⁺γδ T cells

Control of γδ T-cell activation remains incompletely understood. Here the authors show that during autoimmune arthritis development αβ CD4⁺T cells recruit a subset of IL-17-producing γδ T cells to the joints, and that both components are essential to cause pathology in a mouse model of the disease.

Aoi Akitsu
Harumichi Ishigame
Yoichiro Iwakura
ResearchOpen Access25 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice

Masataka Iida
Mark Joseph Desamero
Kazuhiro Hirayama
ResearchOpen Access01 Jul 2021
Scientific Reports

Volume: 11, P: 1-13
Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma

Mark Joseph Desamero
Shigeru Kakuta
Shigeru Kyuwa
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
Effector memory CD4⁺T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance

Aiko Ono-Ohmachi
Satoki Yamada
Haruyo Nakajima-Adachi
Research29 Jul 2021
Mucosal Immunology

Volume: 14, P: 1335-1346
A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

Nakatsuka et al. discover that the adipokine vaspin contributes to maintaining proximal tubular cell (PTC) homeostasis by ameliorating organelle stress. They find that upon internalization, vaspin interacts with the heat shock protein HSPA1L and that the proteins cooperate to prevent metabolic stress-induced cellular injuries in PTCs.

Atsuko Nakatsuka
Satoshi Yamaguchi
Jun Wada
ResearchOpen Access19 Mar 2021
Communications Biology

Volume: 4, P: 1-16
Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

Tsuneo Ikenoue
Yumi Terakado
Yoichi Furukawa
ResearchOpen Access31 Jan 2018
Scientific Reports

Volume: 8, P: 1-9

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Ferroelectric Polarization Reversal Stabilized by Hydrogen Bonding in N-Phenylated Aromatic Polyurea

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T_reg cells through modification of the intestinal microbiota

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2⁺Vγ6⁺γδ T cells

Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice

Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma

Effector memory CD4⁺T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance

A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

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