Lung squamous cell carcinoma (LSCC) is a common subtype of lung cancer with high malignancy. The authors show that the kinase PAK2 binds to the transcription factor SOX2 and activates the oncogene DEK, thus contributing to the malignant behavior of LSCC cells. This work provides new therapeutic targets and insightful information for enhancing targeted therapy of LSCC.
- Shiguang Xie
- Xuan Wan
- Xiaoming Liu
