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Showing 1–2 of 2 results
Advanced filters: Author: Shijay Gao Clear advanced filters

  • B cell receptor (BCR) activation can trigger signalling causing apoptosis in order to eliminate auto-reactive B cells. Here the authors show that the O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 are involved in a switch that regulates the initiation of apoptosis induced by BCR cross-linking.

    • Jung-Lin Wu
    • Hsin-Yi Wu
    • Kuo-I. Lin
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial β-glucuronidases (GUSs). The authors present eight crystal structures and demonstrate in vivo efficacy of the optimised C6-alkyl derivative inhibitor in mice models. This study may enhance the development of inhibitors of microbial GUS for use in colorectal cancer therapy to minimize the undesired side effects of irinotecan treatment.

    • Hsien-Ya Lin
    • Chia-Yu Chen
    • Chun-Hung Lin
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10