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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade

Macrophages are pleiotropic and can have different functions and phenotypes. Here the authors show that a population of macrophages, previously described as pro-fibrotic, can be induced through Notch2 blockade and that in a mouse lung injury and fibrosis model this macrophage population does not promote inflammation or fibrosis.

Mayra Cruz Tleugabulova
Sandra P. Melo
Maximilian Nitschké
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-18
The Mesangial cell — the glomerular stromal cell

Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. This Perspective reviews advances in our understanding of mesenchymal stromal cell function and describes how these insights can inform our understanding of mesangial cells and their role in disease.

Shimrit Avraham
Ben Korin
Andrey S. Shaw
Reviews10 Sept 2021
Nature Reviews Nephrology

Volume: 17, P: 855-864
Daratumumab for eradication of minimal residual disease in high-risk advanced relapse of T-cell/CD19/CD22-negative acute lymphoblastic leukemia

Yishai Ofran
Shimrit Ringelstein-Harlev
Avraham Frisch
Research21 Aug 2019
Leukemia

Volume: 34, P: 293-295
Preparation of single-cell suspensions of mouse glomeruli for high-throughput analysis

The glomerulus is a difficult-to-isolate structure that is often poorly represented in single-cell kidney preparations. This protocol describes the isolation of high-quality mouse glomerular cells for high-throughput analyses.

Ben Korin
Jun-Jae Chung
Andrey S. Shaw
Protocols19 Jul 2021
Nature Protocols

Volume: 16, P: 4068-4083
ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription

Shimrit Avraham
Ben Korin
Ami Aronheim
ResearchOpen Access22 Jan 2019
Oncogene

Volume: 38, P: 3812-3823

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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade

The Mesangial cell — the glomerular stromal cell

Daratumumab for eradication of minimal residual disease in high-risk advanced relapse of T-cell/CD19/CD22-negative acute lymphoblastic leukemia

Preparation of single-cell suspensions of mouse glomeruli for high-throughput analysis

ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription

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