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Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation

Cdo regulates early forebrain development as a co-receptor of the morphogen Shh and is required for full activation of Shh signalling. Here the authors show that Cdo interacts with the Wnt co-receptor Lrp6, thereby inhibits Wnt signalling and promotes neuronal differentiation.

Myong-Ho Jeong
Seok-Man Ho
Jong-Sun Kang
Research19 Nov 2014
Nature Communications

Volume: 5, P: 1-13

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Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation

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