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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides a resource for potential classifications and targets.

Shideh Mirhadi
Shirley Tam
Ming-Sound Tsao
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

The authors add to our knowledge of the transcriptional regulation of the meiotic program in mice spermatocytes, showing ZFP541 regulates meiotic prophase and transition to the division phase by being the target for upstream factors MEIOSIN/STRA8.

Yuki Horisawa-Takada
Chisato Kodera
Kei-Ichiro Ishiguro
ResearchOpen Access01 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

The regulation of meiotic prophase progression varies between males and females. This study reveals the involvement of an atypical heat shock transcription factor HSF5 in gene expression during male meiotic prophase and highlights the involved gene regulatory mechanism.

Saori Yoshimura
Ryuki Shimada
Kei-ichiro Ishiguro
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-22
Machine learning assisted optimization of blending process of polyphenylene sulfide with elastomer using high speed twin screw extruder

Shingo Takada
Toru Suzuki
Satoshi Yoda
ResearchOpen Access15 Dec 2021
Scientific Reports

Volume: 11, P: 1-9
Extracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer

Masahiro Adachi
Tetsuro Taki
Shingo Sakashita
ResearchOpen Access24 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma

Yunjung Kim
Aya Shiba-Ishii
Masayuki Noguchi
Research07 Jun 2018
Oncogene

Volume: 37, P: 5387-5402

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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

Machine learning assisted optimization of blending process of polyphenylene sulfide with elastomer using high speed twin screw extruder

Extracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma

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