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Showing 1–2 of 2 results
Advanced filters: Author: Shinichi Okudaira Clear advanced filters

  • :Autotaxin (ATX) is a secreted enzyme that produces lysophosphatidic acid (LPA), which in turn activates GPCRs to elicit cellular responses. The crystal structures of mouse ATX in its apo state and bound to different LPAs and functional work reveal a hydrophobic tunnel that could participate in direct delivery of the product to its cognate GPCRs.

    • Hiroshi Nishimasu
    • Shinichi Okudaira
    • Osamu Nureki
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 205-212

  • SELEX selections and crystallographic analyses have allowed development of a DNA aptamer that inhibits autotaxin with high potency and specificity, and exhibits efficacy against bleomycin-induced pulmonary fibrosis in model mice.

    • Kazuki Kato
    • Hisako Ikeda
    • Osamu Nureki
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 395-401