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Showing 1–6 of 6 results
Advanced filters: Author: Shira Roth Clear advanced filters
  • Idiopathic pulmonary fibrosis is characterised by the accumulation of fibroblasts, which deposit excessive extracellular matrix impairing respiratory functions. Here, the authors show that fibroblast-expressed versican, a chondroitin sulphate proteoglycan, suppresses fibroblasts’ ability to invade and further grow the underlying matrix, thus limiting their accumulation and attenuating pulmonary fibrosis.

    • Paraskevi Kanellopoulou
    • Ilianna Barbayianni
    • Vassilis Aidinis
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-23
  • Here authors identify GluN2D-containing NMDA receptors on interneurons as a specific target for rapid antidepressant action. Blocking GluN2D restores stress-impaired plasticity and mimics the effects of ketamine with fewer side effects.

    • Stefan Vestring
    • Maxime Veleanu
    • Claus Normann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26
  • Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, but their antibacterial properties can be overlooked. Here the authors show the antibacterial activity of self-assembled diphenylalanine, which emerges as the minimal model for antibacterial supramolecular polymers.

    • Lee Schnaider
    • Sayanti Brahmachari
    • Ehud Gazit
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10
  • Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.

    • Yimu Zhao
    • Shira Landau
    • Milica Radisic
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 588-608