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Showing 1–7 of 7 results
Advanced filters: Author: Shivang Parikh Clear advanced filters
  • Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.

    • Ohad Glaich
    • Shivang Parikh
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11
  • Chronic UV exposure has been associated with immune system suppression. Here the authors show that enhanced tumor growth and resistance to PD1 blockade in mice exposed to UV irradiation is associated with induced expression of Ly6a in CD8 + T cells and that targeting Ly6a enhances anti-tumor immune responses in models resistant to anti-PD1.

    • Avishai Maliah
    • Nadine Santana-Magal
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Batista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize the requirements of 10E8 B cell precursors for entry and maturation in the germinal center.

    • Rashmi Ray
    • Torben Schiffner
    • Facundo D. Batista
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1083-1096
  • Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.

    • Danna Sheinboim
    • Itay Maza
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12