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Advanced filters: Author: Shivashankar Othy Clear advanced filters

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming

T regulatory cells (Tregs) prevent immunopathology by inhibiting excessive T-cell activation. Here the authors show interactions between dendritic cells, Tregs and antigen-specific T cells in the lymph node during initiation of the immune response in real time by two-photon microscopy.

Melanie P. Matheu
Shivashankar Othy
Michael D. Cahalan
Research05 Feb 2015
Nature Communications

Volume: 6, P: 1-11
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarization responses.

Hamza Atcha
Amit Jairaman
Wendy F. Liu
ResearchOpen Access31 May 2021
Nature Communications

Volume: 12, P: 1-14
Polymodal K⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines

A dual potassium channel functional screen of 1444 plant extracts uncovers unexpected molecular mechanisms underlying the traditional use of witch hazel and fireweed as analgesic, anti-inflammatory medicines.

Rían W. Manville
Ryan F. Yoshimura
Geoffrey W. Abbott
ResearchOpen Access28 Aug 2024
Communications Biology

Volume: 7, P: 1-18

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