Notch1 activation in cancer is regulated through phosphorylation of Notch1 intracellular domain. Here, the authors find that DUSP6 functions as a phosphatase for Notch1 transmembrane/intracellular domain (NTM) to increase NTM protein stability and promote colorectal cancer progression.
- Chin Wen Png
- Madhushanee Weerasooriya
- Yongliang Zhang
