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Nature Immunology (1)

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Advanced filters: Author: Shoba L Subramanian Clear advanced filters

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Pancreatic islets in type 2 diabetes show characteristic deposition of the amyloid polypeptide IAPP. O'Neill and colleagues show that IAPP induces IL-1β production via the NLRP3 inflammasome, which leads to beta-cell destruction.

Seth L Masters
Aisling Dunne
Luke A J O'Neill
Research12 Sept 2010
Nature Immunology

Volume: 11, P: 897-904

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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