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Showing 1–2 of 2 results
Advanced filters: Author: Shoichiro Miyatake Clear advanced filters

  • Ionizing radiation damages small intestinal crypt cells, including epithelial stem cells and their progeny. Here the authors show that radiation-induced crypt cell death is amplified by the release of cellular RNA from apoptotic epithelial cells, which then triggers pro-apoptotic TLR3 signalling on neighbouring cells.

    • Naoki Takemura
    • Takumi Kawasaki
    • Satoshi Uematsu
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-15

  • The molecular basis of TH2 lineage commitment is poorly understood. Kubo and colleagues identify the Il4 enhancer HS2 as a target of the transcription factor GATA-3 and show it to be critical for IL-4 production and TH2 functional commitment.

    • Shinya Tanaka
    • Yasutaka Motomura
    • Masato Kubo
    Research
    Nature Immunology
    Volume: 12, P: 77-85