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A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viral pathogenesis

Rice stripe virus deploys its SP protein to dismantle SERRATE condensates in rice cells, blocking microRNA production and enhancing viral spread. This discovery reveals how viruses can hijack host phase separation to modulate gene regulation.

Jing Zou
Shuai Zhang
Jianguo Wu
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Possible new RNA intermediate in RNA silencing

SGS3 is essential for antiviral silencing and the biogenesis of several classes of siRNAs in plants, but until now no biochemical function has been ascribed to it. Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

Samer Elkashef
Shou-Wei Ding
News & Views01 May 2009
Nature Chemical Biology

Volume: 5, P: 278-279
Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana

Whether natural variations of plant virus resistance are enriched in genes of RNA interference pathway is unknown. Here, via genome-wide association studies, the authors identify regulators of the RDR6 and DCL2 antiviral pathways are involved in quantitative resistance to cucumber mosaic virus in Arabidopsis.

Si Liu
Meijuan Chen
Shou-Wei Ding
ResearchOpen Access30 May 2022
Nature Communications

Volume: 13, P: 1-10
Cotton plants export microRNAs to inhibit virulence gene expression in a fungal pathogen

Fungi are the most prevalent class of plant pathogens, causing many diseases in crops. The authors show that in order to fight against them, plants produce and export miRNAs to silence important fungal genes, reducing the pathogen's virulence.

Tao Zhang
Yun-Long Zhao
Hui-Shan Guo
Research26 Sept 2016
Nature Plants

Volume: 2, P: 1-6
Reply to ‘Questioning antiviral RNAi in mammals’

Kate L. Jeffrey
Yang Li
Shou-wei Ding
Correspondence25 Apr 2017
Nature Microbiology

Volume: 2, P: 1-2
RNA-based antiviral immunity

Virus infection in a wide range of eukaryotic host species results in the production of virus-derived small RNAs (such as small interfering RNAs) that specifically target the virus genome through RNA interference and related RNA silencing mechanisms. In this manner, virus-derived small RNAs mediate a form of antiviral immunity.

Shou-Wei Ding
Reviews13 Aug 2010
Nature Reviews Immunology

Volume: 10, P: 632-644
Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells

Influenza virus infection produces double-stranded RNA precursors that are converted to small interfering RNAs by host Dicer; this RNA interference mechanism is inhibited by viral protein NS1.

Yang Li
Megha Basavappa
Kate L. Jeffrey
Research05 Dec 2016
Nature Microbiology

Volume: 2, P: 1-9
Small RNA-based antimicrobial immunity

The authors review the latest research revealing conserved antiviral activity of virus-derived small interfering RNAs (siRNAs) in fungi, plants, invertebrates and mammals.

Zhongxin Guo
Yang Li
Shou-Wei Ding
Reviews09 Oct 2018
Nature Reviews Immunology

Volume: 19, P: 31-44
Viral effector protein manipulates host hormone signaling to attract insect vectors

Dewei Wu
Tiancong Qi
Daoxin Xie
Research06 Jan 2017
Cell Research

Volume: 27, P: 402-415
Genome-wide identification of endogenous RNA-directed DNA methylation loci associated with abundant 21-nucleotide siRNAs in Arabidopsis

Jian-Hua Zhao
Yuan-Yuan Fang
Hui-Shan Guo
ResearchOpen Access27 Oct 2016
Scientific Reports

Volume: 6, P: 1-13

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A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viral pathogenesis

Possible new RNA intermediate in RNA silencing

Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana

Cotton plants export microRNAs to inhibit virulence gene expression in a fungal pathogen

Reply to ‘Questioning antiviral RNAi in mammals’

RNA-based antiviral immunity

Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells

Small RNA-based antimicrobial immunity

Viral effector protein manipulates host hormone signaling to attract insect vectors

Genome-wide identification of endogenous RNA-directed DNA methylation loci associated with abundant 21-nucleotide siRNAs in Arabidopsis

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