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Showing 1–20 of 20 results
Advanced filters: Author: Shoukhrat Mitalipov Clear advanced filters

  • CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 548, P: 413-419

  • Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

    • Nuria Marti Gutierrez
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Mutations in mitochondrial DNA cause a wide range of disorders in humans, with a high prevalence; here it is shown that the nucleus of an affected woman’s egg could be inserted into healthy donor egg cytoplasm by spindle transfer, allowing the birth of healthy offspring.

    • Masahito Tachibana
    • Paula Amato
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 493, P: 627-631

  • Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

    • Eunju Kang
    • Jun Wu
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 540, P: 270-275

  • Reprogramming after somatic cell nuclear transfer had been thought to be dependent on the recipient cytoplasm being arrested at the metaphase stage, but here interphase two-cell mouse embryos are shown to support successful reprogramming and generation of embryonic stem cells or cloned mice.

    • Eunju Kang
    • Guangming Wu
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 509, P: 101-104

  • DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

    • Dan Liang
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Genome-wide analysis of matched human IVF embryonic stem cells (IVF ES cells), induced pluripotent stem cells (iPS cells) and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear transfer (SCNT) reveals that human somatic cells can be faithfully reprogrammed to pluripotency by SCNT; NT ES cells and iPS cells derived from the same somatic cells contain comparable numbers of de novo copy number variations, but whereas DNA methylation and transcriptome profiles of NT ES cells and IVF ES cells are similar, iPS cells have residual patterns typical of parental somatic cells.

    • Hong Ma
    • Robert Morey
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 511, P: 177-183

  • Genetically engineered monkeys carrying a foreign gene that is passed on to their offspring provide a potentially valuable bridge between mouse models of disease and treatment for human disorders.

    • Gerald Schatten
    • Shoukhrat Mitalipov
    News & Views
    Nature
    Volume: 459, P: 515-516

  • Mutations in mitochondrial (mt)DNA are associated with severe disorders for which treatment is currently limited; this study shows that mtDNA mutations can be genetically corrected and normal metabolic function restored in cells derived from patients with mtDNA disease and reprogrammed to pluripotency through factor-mediated reprogramming or via a somatic cell nuclear transfer approach.

    • Hong Ma
    • Clifford D. L. Folmes
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 524, P: 234-238

  • The mitochondrial genome is of maternal origin and mutations in mitochondrial DNA are the cause of many human diseases. The efficient replacement of the mitochondrial genome in mature non-human primate oocytes is now demonstrated. This approach may offer a reproductive option to prevent the transmission of diseases caused by mutations in mitochondrial DNA in affected families.

    • Masahito Tachibana
    • Michelle Sparman
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 461, P: 367-372

  • Germline gene therapy has the potential to prevent inheritance of monogenic disorders but must first be optimized for accuracy.

    • Don P. Wolf
    • Paul A. Mitalipov
    • Shoukhrat M. Mitalipov
    Reviews
    Nature Medicine
    Volume: 25, P: 890-897

  • The mitochondrial transcription factor A is excluded from the mitochondria in spermatozoa by virtue of phosphorylation of the mitochondrial presequence. This is associated with transport to the nucleus and loss of mitochondrial DNA (mtDNA) from the mitochondria, providing a mechanistic basis for uniparental inheritance of mtDNA in humans.

    • William Lee
    • Angelica Zamudio-Ochoa
    • Dmitry Temiakov
    Research
    Nature Genetics
    Volume: 55, P: 1632-1639

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 560, P: E10-E23

  • Yeonmi Lee, Aysha Trout, Nuria Marti-Guiterrez et al. examine different aspects of somatic cell haploidization in mouse enucleated oocytes. Their results provide further insight into generating oocytes carrying somatic genomes.

    • Yeonmi Lee
    • Aysha Trout
    • Eunju Kang
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15