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Showing 1–4 of 4 results
Advanced filters: Author: Shraddha Pai Clear advanced filters

  • Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.

    • Mohsen Hosseini
    • Veronique Voisin
    • Steven M. Chan
    Research
    Nature
    Volume: 642, P: 421-430

  • Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis.

    • Shraddha Pai
    • Peipei Li
    • Viviane Labrie
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Chemical modifications of CpG dinucleotides form part of the epigenetic code and various methods for the detection of modified CpG sites exist. Here Kriukiene and colleagues report a complementary method that allows the profiling of unmodified CpG sites within the genome, which they call the 'unmethylome'.

    • Edita Kriukienė
    • Viviane Labrie
    • Saulius Klimašauskas
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • The 5-hydroxymethylcytosine (5-hmC) nucleoside is abundant in the brain for unknown reasons. Genome-wide analysis of the distribution of 5-hmC versus 5-methylcytosine (5-mC) in human and mouse tissues now shows that 5-hmC is enriched in genes with synaptic functions. The differential distribution of 5-hmC versus 5-mC at exon-intron boundaries in both human and mouse tissues further suggests a possible role for 5-hmC in pre-mRNA splicing.

    • Tarang Khare
    • Shraddha Pai
    • Arturas Petronis
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1037-1043