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Showing 1–2 of 2 results
Advanced filters: Author: Shreyas Supekar Clear advanced filters

  • GPR84 is an important GPCR regulating macrophage function. Here, the authors show the pro-phagocytic function of the GPR84-Gi signaling axis in native macrophages and determine a cryo-EM structure of the GPR84-Gi complex with a synthetic agonist.

    • Xuan Zhang
    • Yujing Wang
    • Cheng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.

    • Qingpin Xiao
    • Lei Wang
    • Cheng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11