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Showing 1–3 of 3 results
Advanced filters: Author: Shruti Regmi Clear advanced filters

  • TH1760 is a first-in-class, potent, selective and cell-active inhibitor against human NUDT15, which sensitizes cells to 6-thioguanine treatment. TH1760 represents a valuable tool for deciphering the enigmatic functions of NUDT15.

    • Si Min Zhang
    • Matthieu Desroses
    • Thomas Helleday
    Research
    Nature Chemical Biology
    Volume: 16, P: 1120-1128

  • NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells.

    • Brent D. G. Page
    • Nicholas C. K. Valerie
    • Thomas Helleday
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14